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Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

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Phase N/A

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Overview

This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers. Researchers want to identify risk factors for developing these blood cancers as well as if there is/are a genetic/environmental component(s) to developing blood cancer.

Description

OUTLINE: This is an observational study.

Patients undergo blood sample collection and complete surveys on study. Patients' medical records are also reviewed.

Eligibility

Inclusion Criteria:

  • Subjects who have or have had ovarian, peritoneal, or fallopian tube carcinoma who have a life expectancy of greater than 6 months and:
    • Have completed or plan to complete at least 5 cycles of platinum-based chemotherapy

OR

  • Subjects who have or have had a solid tumor diagnosis and any of the following:
    • At least 4 months of exposure to a PARP inhibitor
    • Diagnosis of a blood disorder including, but not limited to, clonal hematopoiesis of indeterminate potential, cytopenia of unknown significance, or therapy-related myeloid neoplasm

Exclusion Criteria:

  • Individuals with a life expectancy of less than 6 months

Study details
    Recurrent Fallopian Tube Carcinoma
    Recurrent Ovarian Carcinoma
    Recurrent Primary Peritoneal Carcinoma
    Recurrent Malignant Solid Neoplasm
    Clonal Cytopenia of Undetermined Significance
    Clonal Hematopoiesis
    Idiopathic Cytopenia of Undetermined Significance
    Non-Neoplastic Hematopoietic and Lymphoid Cell Disorder
    Ovarian Carcinoma
    Myeloid Neoplasm Post Cytotoxic Therapy

NCT06295965

University of Washington

15 May 2026

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