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REALITY MONITORING

Recruiting
18 - 45 years of age
Both
Phase N/A

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Overview

Reality-monitoring characterizes the ability to determine whether information was perceived in the environment or only imagined . Impaired reality-monitoring abilities have been associated with hallucinations in patients with schizophrenia and patients with Parkinson's disease.

The investigators hypothesize a link between dopaminergic (DA) transmission and reality-monitoring.

Description

This hypothesis is based on several studies in the literature: 1) DA transmission anomalies are observed in both schizophrenia and Parkinson's disease; 2) DA agonists may induce hallucination; 3) DA antagonists reduce hallucinations and improve reality-monitoring abilities in patients with schizophrenia. In addition, also suggesting a link between mesocorticolimbic connectivity, subcortical DA transmission and reality-monitoring, The investigators have shown that fronto-temporal transcranial Direct Current Stimulation (tDCS)

leads
  • on the one hand, to modulate reality-monitoring performance in healthy volunteers and patients;
  • on the other hand, to induce subcortical DA release. However, to date, no study has yet explored the direct link between DA transmission and reality-monitoring.

Eligibility

Inclusion Criteria:

  • Healthy volunteers who have given their written informed consent
  • Men and women from 18 to 45 years old
  • Normal or corrected vision
  • Being fluent in French or French for native language
  • Being affiliated with health insurance

Exclusion Criteria:

  • Healthy volunteers who have given their written informed consent
  • Men and women from 18 to 45 years old
  • Normal or corrected vision
  • Being fluent in French or French for native language
  • Being affiliated with health insurance
  • Inadmissibility of the subject's consent or refusal
  • Working-memory deficit (as controlled with MMSE score< 23)
  • Any past or current psychiatric or somatic condition(as controlled with the Mini International Neuropsychiatric Interview, MINI)
  • Any past or current neurological condition
  • History of cranio-cerebral trauma, arterial hypotension or hypertension, cardiological or serious medical condition
  • Abnormal potassium dosage (below 3.1 mmol/L or above 4.9 mmol/L)
  • Anormal ECG
  • History of schizophrenia or bipolar disorder in first-degree relatives
  • Alcohol-drinking and caffeine intake at least during 24 hours before each session
  • Drug therapy excepting contraceptives
  • Cardiologic or severe medical conditio
  • Pregnancy(checked with a pregnancy autotest), lactation, or insufficient contraceptive measure (precautionary measure)
  • Consumption of recreational drugs during the last 6 months
  • Known sensitivity to any of the study medication and their excipients
  • Lactose intolerance
  • Porphyria
  • Hepatic insufficiency

Study details

Neurosciences

NCT05711082

Hôpital le Vinatier

22 February 2024

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