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A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)

Recruiting
18 years and older
All
Phase 3
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Overview

The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.

Eligibility

Inclusion Criteria:

  • B/S1 hypertension
  • SBP 100-139 average based on 3 office measurements.
  • Age 18 or Older
  • Previous COA Repair

Exclusion Criteria:

  • Currently on beta blocker (BB) therapy
  • Pregnancy/lactating
  • eGFR\<30
  • Hyperkalemia (serum potassium \>5.5mmol/L)
  • Severe Aortic or Mitral valve stenosis or regurgitation
  • Epicardial CAD diagnosis
  • Received antihypertensive medications within the past year

Study details
    Coarctation of Aorta
    High Blood Pressure

NCT06150560

Mayo Clinic

14 May 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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