Overview
This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.
Eligibility
Inclusion Criteria:
- Obese men and women ≥ 20 and ≤ 45 years of age.
Exclusion Criteria:
- Diabetes or fasting plasma glucose \>126 mg/dL
- Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
- Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
- Renal failure (serum creatinine \> 1.5mg/dl)
- Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
- Oral warfarin group medications or history of blood clotting disorders.
- Smoking
- Pregnancy or breastfeeding
- Alcohol consumption greater than 2 glasses/day or other substance abuse
- Untreated or uncontrolled hypothyroidism
- Debilitating chronic disease (at the discretion of the investigators)
