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Mindfulness-Based Relapse Prevention for Opioid and Alcohol Use Disorders

Mindfulness-Based Relapse Prevention for Opioid and Alcohol Use Disorders

Non Recruiting
18 years and older
All
Phase N/A

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Overview

A randomized controlled trial will examine mindfulness-based relapse prevention (MBRP) program outcomes for 240 individuals who have completed treatment for opioid or alcohol use disorders. MBRP is a group aftercare program that integrates mindfulness skills training with cognitive-behavioral relapse prevention strategies. Primary outcomes will include frequency of opioid/alcohol use, craving, withdrawal, and quality of life. Secondary outcomes include time to first opioid/alcohol use, adherence to medication-assisted treatment plans, perceived stress, posttraumatic stress symptoms, and chronic pain. We will also examine the following potential moderators of intervention outcomes: comorbid diagnoses, life events history, and MBRP intervention adherence. In addition, we will examine the following mediators of intervention outcome: mindfulness skills, emotion regulation skills, executive functioning skills, savoring, and positive and negative affect.

Description

A randomized controlled trial will examine mindfulness-based relapse prevention (MBRP) program outcomes for 240 individuals who have completed treatment for opioid or alcohol use disorders. Participants will be recruited from outpatient medical clinics and substance use recovery centers. They will be assigned to an intervention group (Group 1) or waitlist control (Group 2), completing assessments at baseline, 8, and 16 weeks. Group 1 will receive the intervention in weeks 1-8 and group 2 will receive the intervention in weeks 9-16. MBRP is a group aftercare program that integrates mindfulness skills training with cognitive-behavioral relapse prevention strategies. Primary outcomes will include frequency of opioid/alcohol use, craving, withdrawal, and quality of life. Secondary outcomes include time to first opioid/alcohol use, adherence to medication-assisted treatment plans, perceived stress, posttraumatic stress symptoms, and chronic pain. We will also examine the following potential moderators of intervention outcomes: comorbid diagnoses, life events history, and MBRP intervention adherence. In addition, we will examine the following mediators of intervention outcome: mindfulness skills, emotion regulation skills, executive functioning skills, savoring, and positive and negative affect.

Eligibility

Inclusion Criteria:

  • over 18 years of age
  • completed behavioral health treatment for Opioid Use Disorder (OUD) or Alcohol Use Disorder (AUD) within the previous eight weeks
  • continues to be followed by a behavioral health provider
  • meets DSM-5 criteria for OUD or AUD
  • English fluency
  • able to attend intervention sessions

Exclusion Criteria

  • current psychosis
  • dementia
  • moderate to severe traumatic brain injury
  • pregnancy
  • active suicidality
  • persistent antisocial behavior
  • acute episode of an SUD (past two weeks)
  • persistent self-injury requiring clinical management
  • already completed or attending a mindfulness-based intervention

Study details
    Opioid-use Disorder
    Opioid Abuse
    in Remission
    Alcohol Use Disorder
    Alcohol Use Disorder
    in Remission

NCT04278352

Clemson University

20 August 2025

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