Overview
To evaluate the role of ANGPTL3, on lipid metabolism. To explore the role of this protein on glucose metabolism.
Description
Oral fast tolerance test, lipoprotein kinetics and a glucose tolerance test to evaluate the role of ANGPTL3, on lipid metabolism and to explore the role of this protein on glucose metabolism.
Eligibility
Inclusion Criteria:
- Subjects aged 18 or older meeting at least one of the following criteria
- Carrying genetic variants in the gene encoding for ANGPTL3,
- Unaffected controls matched for age, race, gender,
- Willing to follow study procedures
- Able to provide inform consent
Exclusion Criteria:
- Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Women that are pregnant or nursing
- History of liver disease or abnormal liver function tests (\>2x upper limit of normal)
- History of kidney disease or chronic renal insufficiency (eGFR \<60 mL/min/1.73 m2)
- Uncontrolled hypertension (\>160/100 mmHg)
- Uncontrolled diabetes
- Anemia (hemoglobin \<11.0 mg/dL) History of a non-skin malignancy within the previous 5 years Major surgery within the past 3 months
- History of any organ transplant
- History of alcohol or drug abuse
- Participation in clinical trials assessing the efficacy and safety of drugs affecting lipid metabolism within the past 6 weeks (or longer depending on the known half-life of the drug) that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
- Inability to comply to study procedures
