Overview
The proposed study has two primary objectives i.e. to examine how improvements in diet quality via a personalized dietary intervention 1) benefit cardiometabolic outcomes in young Black adults differentially compared to non-Hispanic White adults, and 2) improve carbohydrate and lipid metabolism in relation to the gut microbiome.
Description
The study is an 8-wk randomized, controlled, parallel arm clinical trial in which participants (age: 18-35 years, BMI: 25-45 kg/m2, race/ethnicity: Black or White) will be block randomized to a personalized dietary intervention or to receive conventional dietary advice. Outcomes assessed will include metabolites involved in carbohydrate and lipid regulation, gut microbiome composition, and cardiometabolic biomarkers.
Eligibility
Inclusion criteria:
- Age: 18-35 years of age
- BMI: 25-45 kg/m2
- Black including those of Hispanic ethnicity, and Non-Hispanic White individuals
- Willingness to consume nuts, fruits and vegetables
- Willing to comply with study protocol
- Consistent diet and activity patterns for 4 weeks
- Weight stable (≤5 kg change over the last 3 months) (Self-reported)
- Non-smoker >1 year or more
Exclusion Criteria:
- Allergies to fruits, vegetables, and nuts provided in the study
- Illicit drug use
- Recent start of medications that affect metabolism or appetite
- Antibiotics
- Coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia requiring drug therapy
- Uncontrolled hypertension and blood pressure ≥ 180/110 Diabetes
- Gastrointestinal disease and/or bariatric surgery
- HIV positivity
- Pregnant or lactating individuals
