Overview
About 20,000 patients with FFR (Fractional Flow Reserve) will be enrolled and evaluated for the natural history of coronary lesions at 2 years clinical and imaging follow-up.
Description
This is a multicenter, prospective cohort. About 20,000 patients with FFR will be enrolled at multi centres in Korea.
Eligibility
Inclusion Criteria:
- Age 35 years and older
- FFR measurement on one and more coronary artery stenosis
- Willing and able to provide informed, written consent
Exclusion Criteria:
- Stenosis with TIMI\<3 flow
- Graft vessel
- Ejection fraction \< 30%
- Angiographic evidence of extreme tortuosity or calcified coronary vessels
- Suspected coronary spasm even after sufficient nitrate injected
- Life expectancy \<2 year
- Planned cardiac surgery or planned major non cardiac surgery
- Woman who are breastfeeding, pregnant or planning to become pregnant during the course of the study
Imaging study specific exclusion criteria
- visually-estimated angiographic reference segment diameter of \<2.75mm or \>4.0mm
- Inappropriate for IVUS/VH/OCT procedures : inability for imaging wire or catheter to pass through the tight stenosis, severe calcification, angulation
