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Conditioning Electrical Stimulation to Improve Outcomes in Cubital Tunnel Syndrome

Conditioning Electrical Stimulation to Improve Outcomes in Cubital Tunnel Syndrome

Recruiting
18-79 years
All
Phase N/A

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Overview

Cubital tunnel syndrome is the second most common compression neuropathy. In severe cases, functional recovery, even with surgery, is often poor. Therefore, alternative adjunct treatments capable of increasing the speed of nerve regeneration are much needed.

Description

The effect of brief conditioning electrical stimulation on nerve regeneration has been showed to be efficacy in animal studies. In this double-blind, randomized, controlled study, the investigators will compare the physiological and functional improvements post surgery compared with the controls who received surgery alone. Because electrical stimulation is reasonably well-tolerated and the treatment only takes an hour, it is a potentially feasible clinical tool for patients with severe nerve injury.

Eligibility

Inclusion Criteria:

  1. Patients aged \>18 yr,
  2. If signs and symptoms of severe CuTS (ie, McGowan-Goldberg grade 3) were observed,
  3. If needle EMG examination showed evidence of chronic motor axonal loss and reduced recruitment in the ulnar-innervated intrinsic hand muscles, and
  4. If electrophysiologic evidence of severe motor axonal loss with motor unit number estimation (MUNE) greater than 2 standard deviations below the normative mean.

Exclusion Criteria:

1\) Patients were excluded if they had concurrent nerve injury, prior surgery for CuTS or coexisting neurologic conditions

Study details
    Cubital Tunnel Syndrome
    Electrical Stimulation

NCT05395715

University of Alberta

13 May 2026

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