Overview

The exact underlying mechanisms of ulcerative colitis (UC), an idiopathic, chronic inflammatory disease marked by diffused inflammation of the colon and rectum mucosa, are still unknown. Due to genetic, immune, and environmental factors, UC is highly dependent on cellular immune reactions and exaggerated inflammatory responses. The release of several cytokines, kinins, leukotrienes, platelet-activating factor (PAF), and reactive oxygen species is connected to immunological activity (ROS). Additionally, many of the cytokines will start an acute phase response, making the inflammation worse.

Eligibility

Inclusion Criteria:

        Age ≥ 18 years Both males and females will be included Negative pregnancy test and
        effective contraception
        Exclusion Criteria:
        - Breastfeeding Significant liver and kidney function abnormalities Colorectal cancer
        patients Patients with severe UC Patients taking rectal or systemic steroids Known allergy
        to the studied medications