Overview
Modifications of cell surface markers (including EMMPRIN) were observed in conjunctival epithelial cells during dry eye syndrome ; this study aims to describe the modifications of the repartition of these cell surface markers before and after initiation of a treatment.
Eligibility
- Patients
Inclusion criteria
- 18 years and over
- Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
- Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced
Exclusion criteria - Known pregnancy or breastfeeding
Control subjects:
Inclusion criteria
\- 18 years and over
Exclusion criteria
- Wearer of contact lenses
- Topical ocular treatment
- Known pregnancy or breastfeeding
