Overview
A randomized within-subject crossover trial to compare the effects of live and recorded music listening on biomarkers of stress and pain among children receiving mechanical ventilation in the pediatric intensive care unit.
Description
Children who are critically ill and receiving mechanical ventilation are at increased risks for experiencing high levels of stress and pain, which negatively impacts immediate and long-term health. The current standard of care for treating stress and pain is to provide analgesic and sedative medications, which are associated with increased risk of delirium and posttraumatic stress disorder. This randomized within-subject crossover trial will compare the effects of live and recorded music listening on biomarkers of stress and pain among children receiving mechanical ventilation in the pediatric intensive care unit, to identify the key components of a music listening intervention and explore its mechanism of action, i.e., the biological pathway through which music listening decreases stress and pain.
Eligibility
Inclusion Criteria:
- 2 months -17 years old
- intubated and receiving MV
- expected to have a PICU stay of \>72 hours
Exclusion Criteria:
- Primary caregiver does not read, write, and speak English
- The child is not expected to survive the PICU stay
- The child has deafness in both ears, has a history of musicogenic epilepsy, is receiving neuromuscular blockade infusion
- The child has a diagnosis of COVID-19
- The child was admitted for a new traumatic brain injury


