Overview
Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.
Description
SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented [1-6]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.
Eligibility
Inclusion Criteria:
- adulthood
- ICU admission
- diagnosis of non-traumatic subarachnoid hemorrhage
Exclusion Criteria:
- inherited coagulation disorder
- rheumatic disease
- microangiopathy
- patient of representative refusal
