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CADASIL Registry Study

CADASIL Registry Study

Recruiting
18-85 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

The aim of this study is to determine the clinical spectrum and natural progression of Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) and related disorders in a prospective multicenter study, to assess the clinical, genetic and epigenetic features of patients with CADASIL , to optimize clinical management.

Eligibility

Inclusion Criteria:

  1. Sign informed consent.
  2. Age>18
  3. Clinical diagnosis of patients with CADASIL,and confirmed by genetic test or skin biopsy
  4. Asymptomatic NOTCH3 mutation carriers
  5. Relatives of CADASIL patients or carriers
  6. Unrelated healthy controls

Exclusion Criteria:

  1. Unable to cooperate with inspectors
  2. Serious systemic illness, such as heart, liver, kidney disease or major mental illness
  3. Contraindications for imaging examination

Study details
    Cadasil

NCT04310098

Bin Cai

26 January 2024

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