Overview
The goal of this clinical trial is to investigate protein digestibility after bariatric surgery.
Does protein digestibility decrease after Roux-en-Y-Gastric Bypass? Does protein digestibility decrease after Sleeve Gastrectomy surgery? Does protein digestibility effect the ability to meet protein requirements?
Description
Purpose of clinical trial is to investigate the digestion of dietary protein in older patients who have undergone Roux-and-Y Bypass (RYGB) or sleeve gastrectomy (SG) surgery. The primary objective is to compare dietary protein digestion during a test meal who have previously undergone a RYGB surgery, SG surgery, or control patients, using a dual stable-isotope method. The secondary objectives are to investigate the relationship between protein intake corrected for protein digestion and skeletal muscle mass, and to investigate the relationship between the rate of free amino acid appearance and protein digestion.
Eligibility
Inclusion Criteria:
- Signed informed consent
- Group 1,2,3: Age 65 years or older
- Group 4,5,6: Age 18 to 65 years
- Group 1,2,4,5: Previous bariatric surgery for obesity 1 - 10 years ago
- Group 3,6: No previous weight loss surgery
Exclusion Criteria:
- Current diagnosis of cancer
- Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4.
- Immobility
- Neuromuscular degenerative conditions
- Gastrointestinal conditions including coeliac disease, Crohn's disease, previous resection of the small intestine, gastroparesis
- Unable to follow the procedures of the studies due to cognitive impairment such as diagnosed dementia.
- Allergy/intolerance to milk, or soy or spirulina
