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Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT

Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT

Recruiting
18 years and older
All
Phase N/A

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Overview

To prospect studying the efficacy and safety of treating NVG with the intracameral versus the intravitreal injection of Bevacizumab.

Description

The present study comparing the safety and efficacy of 1.25mg/0.05mL Bevacizumab injection via the intracameral route versus the intravitreal route in treating the neovascular glaucoma

Eligibility

Inclusion Criteria:

  1. Diagnosis of neovascular glaucoma
  2. The patients having IOP \> 21 mmHg, having the indication for trabeculectomy
  3. The patients' age of at least 18-year-old
  4. The patients having visual potential at least hand motion.
  5. Present of NVI or NVA.
  6. Willing and able to provide informed consent to participate in the study
  7. Able to understand the purpose of the study, his/her role, and is available to return to the clinic/hospital for all required follow-up visits

Exclusion Criteria:

  1. One eye patient
  2. Patients having severe corneal edema or total hyphema obscure NVI or NVA view.
  3. Cannot obtain endothelial cell count.
  4. History of bevacizumab or fluorescence dye allergy.
  5. Active infectious ocular disease including endophthalmitis and corneal ulcer
  6. History of systemic disease including ischemic heart disease, cerebrovascular disease, end-stage renal disease, liver failure, uncontrolled hypertension
  7. Has or planning to be pregnant or breastfeeding

Study details
    Glaucoma
    Neovascular
    Vascular Endothelial Growth Factor Overexpression

NCT03648814

Prince of Songkla University

15 May 2026

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