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Detecting HPV DNA in Anal and Cervical Cancers

Detecting HPV DNA in Anal and Cervical Cancers

Recruiting
18 years and older
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

This is a research study for individuals who have cancer associated with human papillomavirus (HPV) and are being treated with radiation as part of standard care for their cancer. Doctors leading this study will use blood tests to find out if they can detect the HPV virus in the blood of study participants before, during, and after radiation treatment. They will also collect blood and archival tumor tissue (from a previous biopsy) to perform other tests in the future that could provide more information about HPV-associated cancers and how they respond to treatment. Participation in this study will last approximately 2 years.

Eligibility

Inclusion Criteria:

  • Stage I-III anal cancer or stage I-IVA cervical cancer that is p16+ based on immunohistochemistry.
  • Age ≥ 18 years
  • Planned to undergo radiation therapy as definitive treatment, with or without concurrent systemic therapy

Exclusion Criteria:

  • Anal carcinoma not associated with HPV-16, 18, 31, 33, or 35 will be removed from the
  • Planned to undergo radiation therapy as an adjuvant or post-operative therapy

Study details
    Cervical Cancer
    Anal Cancer
    HPV-Related Anal Squamous Cell Carcinoma
    HPV-Related Cervical Carcinoma
    HPV-Related Carcinoma
    Uterine Cervical Cancer

NCT04857528

University of Chicago

15 May 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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