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Randomized Assessment of TcMS for VT Storm

Randomized Assessment of TcMS for VT Storm

Recruiting
18 years and older
All
Phase N/A

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Overview

Three-arm randomized clinical trial comparing two strategies of TcMS to sham stimulation in patients with VT storm. The hypothesis of the study is that TcMS will reduce the burden of VT in the 24 hours after randomization compared to sham stimulation and that TcMS with theta burst stimulation (TBS) will be more effective at reducing VT burden than low frequency TcMS.

Eligibility

Inclusion Criteria:

  • ≥3 episodes of sustained VT or appropriate ICD therapies within 24 hours despite the use of at least one antiarrhythmic drug

Exclusion Criteria:

  • Plan for catheter ablation of VT in the next 24 hours
  • Pregnancy
  • Contraindication to TcMS (i.e. implantable ventricular assist device, metal implanted in the head or neck \[except the mouth\], implanted medication pumps, cochlear implant, implanted brain stimulator, ocular implant, history of malignancy in the neck)

Study details
    Ventricular Tachycardia

NCT05599022

University of Pennsylvania

14 May 2026

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