Overview

The effect of sulthiame on EEG has been studied in epilepsy syndromes of childhood with sleep activation by comparing sleep EEG obtained at baseline and after 4 weeks of treatment. The aim of the study is to know if an effect is still identifiable after 2 weeks of treatment by performing sleep EEG recordings after 2 and 4 weeks of treatment, respectively.

Eligibility

Inclusion Criteria:

• Diagnosis of epilepsy syndromes of childhood with sleep activation
• Failure of at least two anti-epileptic drugs (AED)
• Sleep EEG performed in the last 7 days before inclusion and showing interictal epileptiform discharges (baseline EEG)

Exclusion Criteria:

• Previous trial with sulthiame
• More than 2 AED at inclusion
• Use of corticosteroids at inclusion
• Change in the anti-epileptic treatment in the 7 days before baseline EEG