Efficacy of Vildagliptin Versus Metformin in Poly Cystic Ovary Syndrome

Overview

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects approximately 10-20% of women of reproductive age, Management strategies for PCOS include lifestyle modifications such as diet and physical activity that are the first-line approach to treatment; however, they are reported to be minimally effective in reducing weight or treating PCOS-related symptoms.Pharmacological options are also available; however, they are not explicitly approved for PCOS treatment as they have been primarily used to treat other conditions such as T2DM

Eligibility

Inclusion Criteria:

        -Women diagnosed with PCOS according to Rotterdam 2003 criteria National Institute of
        Health criteria.
        Exclusion Criteria:
          -  Patients with history of diabetes mellitus (Type 1 or 2).
          -  Patients with liver or renal dysfunction; inflammatory diseases; autoimmune disease;
             cancer, acute cardiovascular event within last three months
          -  Known hypersensitivity or contraindications to use dipeptidyl peptidase-4 (DPP-4)
             inhibitors
          -  Eating disorders (anorexia, bulimia) or gastrointestinal disorders