Overview
The purpose of this study is to determine the efficacy and safety of a monoclonal antibody, OpSCF, in the treatment of adults with moderate to severe Atopic Dermatitis (Eczema). OpSCF will be compared to a placebo.
OpSCF or placebo will be administered every 2 weeks for 14 weeks, and the efficacy will be assessed two weeks later. After that, subjects may choose to enter an Open Label Extension phase in which all subjects will receive OpSCF every 4 weeks for 40 additional weeks.
Eligibility
Inclusion Criteria:
- Subject has clinically confirmed diagnosis of active AD
- Subject has at least a 6-month history of AD
- Subject is willing to use effective birth control
Exclusion Criteria:
- Subject is a female who is breastfeeding, pregnant, or who is planning to become pregnant during the study.
- Subject has any clinically significant medical condition that would put the subject at undue risk or interfere with interpretation of study results.
- Subject has used dupilumab within 26 weeks prior to Day 1
- Subject has used tralokinumab within 12 weeks prior to Day 1
