Overview
The aim of this study is to examine in-depth cardiac function and morphology after short-term coronary occlusion by balloon inflation in patients with stable coronary artery disease (CAD) who undergo percutaneous coronary intervention (PCI).
Description
Primary objectives:
- To determine the time-course for the resolution of regional myocardial function after short-term coronary artery occlusion in patients with stable CAD who undergo PCI.
Secondary objectives:
2. To confirm by cardiac magnetic resonance imaging that no myocardial injury occurs after short-term coronary occlusion in patients who undergo PCI due to stable CAD.
3. To establish a clinical model for studying myocardial stunning.
Eligibility
Inclusion Criteria:
- Age >18 years.
- Stable CAD with indication for PCI of a lesion in either of the following coronary
- segments
-
- 6 or 7 (proximal or mid left anterior descending coronary artery)
- 11 (Proximal left circumflex coronary artery)
- 1 or 2 (proximal right coronary artery)
- Normal cardiac function in the myocardial segments subtended by the target vessel, as
assessed by echocardiography at the time of coronary angiography.
- Written informed consent obtained.
Exclusion Criteria:
- Pre-existing heart failure
- Known pre-existing irreversible regional or global wall motion abnormalities affecting the myocardial segments subtended by the target vessel.
- Severe valvulopathy
- Thrombolysis In Myocardial Infarction (TIMI) flow <3 in the target vessel.