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Propofol Versus Esketamine for Rapid Sequence Intubation in Critically Ill Patients

Recruiting
18 years of age
Both
Phase 2
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Overview

Rapid-sequence intubation is routinely performed in critically ill patients. It is unclear whether different sedative agents may influence short-term outcomes after intubation, specially hemodynamic stability.

Eligibility

Inclusion Criteria:

  • Age above 18 years old
  • Physician indicated intubation

Exclusion Criteria:

  • Pregnancy
  • Intubation during cardiac arrest
  • Known of suspected intracranial hypertension
  • Known allergy to propofol or esketamine
  • Bradycardia (heart rate below 50 beats per minute) or atrioventricular block

Study details

Acute Respiratory Failure

NCT05092152

Federal University of São Paulo

25 January 2024

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