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Study of Erythrocyte Parameters and Hypercoagulability in Sickle Cell Disease (SCD-TGA)

Recruiting
18 years of age
Both
Phase N/A
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Overview

Sickle cell disease (SCD) is an inherited haemoglobinopathy disorder caused by mutations in HBB gene with amino-acid substitution on β globin chain. The consequence is synthesis of altered haemoglobin S (HbS) which polymerises in red blood cell (RBC) at deoxygenated state. SCD is associated with chronic haemolytic anaemia, vaso-occlusive crisis (VOC) leading to frequent hospitalisation.

The aim of the study was to to investigate whether a combination of routine laboratory biomarkers of haemolysis could be used to predict VOC development in confirmed SCD patients.

Eligibility

Inclusion Criteria:

  • Sickle cell disease

Exclusion Criteria:

  • <18 years
  • pregnancy
  • Patient under protective guardianship or curatorship

Study details

Sickle Cell Disease, Vaso-occlusive Crisis

NCT05376046

BILLOIR

25 January 2024

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