Overview
The purpose of is study is to investigate whether ischemic postconditioning (iPOST) and intravascular ultrasound-guided (IVUS) percutaneous coronary intervention (PCI) improve the clinical outcome of patients with ST-segment elevation myocardial infarction treated with primary PCI.
Eligibility
Inclusion Criteria:
- Age ≥18 years
- Acute onset of chest pain with <12 hours duration
- STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI.
Exclusion Criteria (iPOST2):
Pre-PCI TIMI flow 0 or 1 Potential pregnancy Inability to provide informed consent
Unwillingness to consent Unavoidable to use thrombectomy Spontaneous coronary artery
dissection Time from symptoms onset to PPCI > 12 hours Culprit in bypass graft Other reason
for not including the patient
Exclusion Criteria (iSTEMI):
Potential pregnancy Inability to understand information in order to provide informed
consent Unwillingness to consent Spontaneous coronary artery dissection Time from symptoms
inset to PPCI > 12 hours Culprit in bypass graft Other reason