Overview
Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients
Description
This is a prospective study to evaluate the safety of donor nephrectomy in HIV+ individuals who donate kidneys to HIV+ candidates in need of transplant . The study will assess potential complications of HIV + living donors - including adverse events related to nephrectomy, development of chronic kidney disease, hypertension, and HIV-related complications.
Eligibility
Inclusion Criteria:
- Able to understand and provide consent
- Age 21 years or older
- Meets standard clinical criteria for living donation per Johns Hopkins University (JHU) Comprehensive Transplant Center Policy
- Documented HIV infection (by any licensed Enzyme-linked Immunosorbent Assay (ELISA) and confirmation by Western Blot, positive HIV Ab Immunofluorescent Assay (IFA), or documented history of detectable HIV-1 RNA)
- CD4+ T-cell count ≥ 500/µL for 6 months prior to donation
- HIV-1 RNA below 50 copies RNA/mL (viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements >200 copies/mL)
Exclusion Criteria:
- Two high risk alleles of APOL1 (G1 or G2 variants)
- Hypertension
- Diabetes
- Chronic active hepatitis C (detectable HCV RNA in plasma)
- Evidence of invasive opportunistic complications from HIV infection
- Mentally incompetent and/or inability to provide informed consent
- Other medical conditions, as determined by the provider, that would preclude donation
