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Comparing SBRT to CRT in Patients With Spinal Metastases

Recruiting
18 - 100 years of age
Both
Phase N/A

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Overview

This is a single institutional registry-based, prospective, observational study to describe radiation oncologists' decision making during evaluation of patients and to compare real-world outcomes of SBRT vs CRT.

A registry-based trial involves observing the effect of something without manipulating it.

Description

The purpose of this study is to study the differences between CRT and SBRT. The investigator's are assessing radiation oncologists' decision-making during the evaluation of patients with spinal metastases by requesting radiation oncologists complete a questionnaire. Additionally, the investigator's will compare outcomes, including local progression, pain response and overall survival between SBRT and CRT. By collecting this information, the investigator's will develop an evidence-based algorithm that may be used to support medical decision-making for others with spinal metastases in the future.

Eligibility

Inclusion Criteria:

  • Adults 18 years of age or older.
  • Patients seen at the Princess Margaret Cancer Centre with painful spinal metastases amenable to radiation treatment.
  • Confirmation of diagnosis: a) Known/documented prior histological cancer diagnosis
  • Able to provide written consent
  • ECOG performance status 0-3

Exclusion Criteria:

  • Prior radiotherapy, with fields overlapping, resulting in excessive doses to organs at risk
  • Lymphoma, myeloma or germ cell malignancies

Study details

Spinal Metastases

NCT05589701

University Health Network, Toronto

25 January 2024

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