Overview
to detect the translocation of c-Myc, Bcl-2 and Bcl-6 by FISH and 481 gene mutation by next generation sequencing and analyze the relationship between this gene abnormalities and the efficacy and prognosis in diffuse large B cell lymphoma.
Description
This is one arm, single center non-intervention study. New diagnosed diffuse large B cell lymphoma patients were enrolled to detect the translocation of c-Myc, Bcl-2 and Bcl-6 by FISH and 481 gene mutation by next generation sequencing, then patients received standard treatment with R-CHOP, R2CHOP and DA-EPOCH by investigate's choice according to the patients pathological characteristics. the basic characteristics and treatment response and progression-free survival and overall survival were collected and analyzed with the gene abnormalities. a total of 100 diffuse large B cell lymphoma patients will enrolled in one year and will finish after 3 years.
Eligibility
Inclusion Criteria:
- ECOG PS 0-2;
- histological diagnosed diffuse large B cell lymphoma;
- normal hematological, hepatal, renal function;
- normal heart function with LVEF ≥ 50%;
Exclusion Criteria:
- Diagnosed as a malignant tumor other than lymphoma or receiving treatment, except for
the following conditions:
①Have received treatment for the purpose of curing, and no malignant tumor with known active disease occurred ≥5 years before enrollment;
②Skin basal cell carcinoma (except melanoma) that has received adequate treatment and has no signs of disease;
③ Carcinoma in situ of the cervix that has received adequate treatment and has no signs of disease.
- Heart disease with clinical significance, including unstable angina pectoris, acute myocardial infarction within 6 months before screening.
- Congestive heart failure (NYHA) heart function is graded in grade III or IV (Annex 3)
- Severe arrhythmia requiring treatment.
- Patients with active hepatitis B and HIV infection.
- Women who are pregnant or breastfeeding
- Patients who have received organ transplants in the past
- Patients with severe active infection
- Have a history of severe neurological or psychiatric diseases, including dementia or epilepsy
