Overview

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Eligibility

Inclusion Criteria:

• 40-80 years of age or with 10 years of firefighting experience
• Current or retired firefighters
• No personal history of lung cancer
• Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study

Exclusion Criteria:

• Any active cancer (undergoing treatment or diagnosed within the past 5 years)