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Molecular Breath Print of COPD Patients With Exacerbations Despite Triple Inhalational Therapy

Recruiting
18 years of age
Both
Phase N/A

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Overview

Determination of specific molecular breath patterns by secondary electrospray ionisation mass spectrometry (SESIHRMS) during and 8 weeks after a COPD exacerbation. Furthermore, breath patterns will be assessed for correlation and association to clinical outcomes and treatment.

Eligibility

Inclusion Criteria:

  • Informed consent
  • age >= 18 years
  • staged according to GOLD recommendations
  • GOLD stage 2-4, risk groups A-D
  • hospitalization due to COPD exacerbation
  • subjects adherent to triple inhalational therapy (beta-2-sympathomimetics, anticholinergics, steroids)
  • suitable for follow-up assessment
  • <48 hours after initiation of antibiotic therapy or systemic steroid therapy

Exclusion Criteria:

  • physical or intellectual impairment precluding informed consent or protocol adherence
  • known pregnancy
  • congenital defects with direct impact on central metabolism e.g. amino acid metabolism defect
  • uncontrolled diabetes (e.g. HbA1c >11% or Glc >20mmol/l).
  • acute or chronic pulmonary disease other than COPD
  • renal failure or renal replacement therapy (GFR < 15 mL/min)

Study details

COPD Exacerbation

NCT04638920

Malcolm Kohler

25 January 2024

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