Overview
The purpose of the CALERIE Legacy Study is to follow up on the health and wellness of participants from phase 2 of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, which was conducted from 2007 to 2011.
Description
The CALERIE Legacy Study is an observational follow-up study of participants from phase 2 the CALERIE trial, the first randomized controlled trial of calorie restriction (CR) in humans without obesity. The overarching goal of the CALERIE Legacy Study is to examine whether two years of CR results in sustained improvements in the biological, phenotypic, and functional hallmarks of human aging 10 to 15 years after the structured intervention. Participants will complete clinical assessments, dietary recalls, and questionnaires, and laboratory evaluations will be performed on blood and urine samples. The study also includes an optional biospecimen banking component.
Eligibility
Inclusion Criteria:
- Enrolled in the CALERIE trial and started their allocated group (CR intervention or ad libitum control condition)
- Willing and able to attend one of the clinical sites for an in-person visit and provide informed consent
Exclusion Criteria:
- Pregnant women
- Women less than 12 months postpartum
- Documented note from the CALERIE trial indicating that the subject should not be contacted or requested not to be contacted for future research
- Diagnosed active cancer or terminal illness