Overview
Exploratory interventional study of prognostic serum biomarkers of cancer progression.
Study of the relationship between the blood levels of soluble PDL1 and β2-microglobulin, and the clinical course of a metastatic solid tumor treated with a first-line therapeutic of checkpoint immune inhibitor.
Description
Primary objective To study the relationship between the blood levels of soluble PDL1 and β2-microglobulin measured at the diagnostic stage, and the clinical course of a metastatic solid tumor (non-small cell lung cancer, kidney cancer, or melanoma) treated with a 1st line therapeutic immune checkpoint inhibitor.
The secondary objectives are:
- To study the relationship between the blood levels of soluble PDL1 and β2-microglobulin measured during treatment, and the clinical course of a metastatic solid tumor treated with a first-line therapeutic immune checkpoint inhibitor.
- To study the correlation between the soluble PDL1 level and the tumor PDL1 level.
- To study the correlation between the blood levels of soluble PDL1 and β2-microglobulin.
- To study the relationship between the blood levels of soluble PDL1 and β2-microglobulin measured during the treatment, and the tolerance of treatment with immune checkpoint inhibitor in 1st line therapy.
Eligibility
Inclusion Criteria:
- Adult patient, male or female, with metastatic cancer of the non-small cell, renal or malignant melanoma type, eligible for treatment with a first-line immune checkpoint inhibitor (immunotherapy alone or in combination with another immunotherapy, chemotherapy or targeted therapy).
- Affiliation to a Social Security organization
- Able to give informed consent to participate in research.
Exclusion Criteria:
- Pregnant women
- Patient under guardianship, curatorship or legal protection
- Patient unable to understand the protocol (language barrier, cognitive difficulties)
- Patient with another active cancer
- Patient with creatinine clearance <60 mL / min
- Patient participating in a therapeutic clinical trial
- Refusal of participation