Overview
This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.
For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.
Eligibility
Inclusion Criteria:
- Patients with diagnosis of pharmaco-resistant focal epilepsy
- Patient candidate for surgery to resect the epileptogenic zone
- Patients affiliated to a social security scheme or beneficiaries of such a scheme
- Patients with French as their mother tongue
- Patients who have given signed informed consent before performing any procedure related to the study.
Exclusion Criteria:
- Contraindication to performing an MRI:
- Intellectual disability objectified by a Mini Mental Score (MMS) score <24 in the year preceding inclusion,
- Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous,
- Participation in other research protocols underway with exclusion period or in the previous week,
- Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.
