Overview
This observational study aims to understand phenotype-specific molecular signatures in patients with complex regional pain syndrome (CRPS).
Description
Participants who meet the diagnostic criteria for CRPS, aged 19~80 years, and agree to participate in this study will undergo a 4mm-sized skin punch biopsy in the involved limb, as well as the contralateral side (internal control).
Spatial transcriptomics will be used to identify immune cell signatures and differentially regulated genes (DEGs) in the epidermis, vasculature, sweat gland, and nerve plexus of the involved ipsilateral (vs contralateral) side of the patient's skin.
Eligibility
Inclusion Criteria:
- Meets the Budapest diagnostic criteria
- Consents to participation in this study
- Aged between 19 and 80 years old
- Symptoms and/or signs of sensory, vasomotor, and sudomotor changes
Exclusion Criteria:
- Who do not agree to participate in this study
- Who has contraindications for skin punch biopsy (e.g. thrombocytopenia, taking anticoagulant drugs)