Overview
AIM: The primary objective of the BeLimumab Antiphospholipid Syndrome Trial (BLAST) is to evaluate the safety and tolerability of belimumab for up to 24 months in patients with persistent aPL positivity and clinical features attributable to aPL that are resistant to warfarin and/or heparin.
Eligibility
Inclusion Criteria:
• Positive aPL profile defined as: Positive lupus anticoagulant test as defined by the
International Society on Thrombosis and Haemostasis, on two or more occasions, at least 12
weeks apart and/or Positive anticardiolipin antibody (aCL) immunoglobulin G(Ig)G/M/A
isotype, present in > 40U, on two or more occasions, at least 12 weeks apart and/or
Positive anti-β2-glycoprotein-I (aβ2GPI) IgG/M/A isotype, present in > 40U, on two or more
occasions, at least 12 weeks apart
AND
• Clinical features attributable to aPL that are resistant to warfarin and/or heparin:
- Recurrent thrombosis despite ongoing anticoagulation and/or
- Persistent thrombocytopenia and/or
- Persistent autoimmune hemolytic anemia and/or
- Cardiac valve disease and/or
- Chronic skin ulcers and/or
- Renal thrombotic microangiopathy and/or
- Cognitive dysfunction with/without white matter changes
Exclusion Criteria:
- >=4/11 American College of Rheumatology Classification Criteria for SLE
- Acute thrombosis (arterial or venous acute thrombosis diagnosis less than 30 days
before study screening)
- History of stroke Acute or chronic pancreatitis
- Pregnancy
- Have a history of malignant neoplasm within the last 5 years except basal cell or
squamous cell carcinoma of the skin treated with local resection only or carcinoma in
situ of the uterine cervix treated locally and with no evidence of metastatic disease
for 3 years
- Have evidence of serious suicide risk including any history of suicidal behaviour in
the last 6 months and/or any suicidal ideation in the last 2 months or who in the
investigator's judgment, poses a significant suicide risk
- Have a history of a primary immunodeficiency
- Have a significant IgG deficiency (IgG level < 400 mg/dL)
- Have an IgA deficiency (IgA level < 10 mg/dL)
- Known active bacterial, viral fungal mycobacterial, or other infection
- Infection history:
- Currently on any suppressive therapy for a chronic infection (such as tuberculosis,
pneumocystis, cytomegalovirus, herpes simplex virus, herpes zoster and atypical
mycobacteria)
- Hospitalization for treatment of infection within 60 days of Day 0.
- Use of parenteral (IV or IM) antibiotics (anti-bacterial, antiviral, anti-fungal, or
antiparasitic agents) within 60 days of Day 0
- Have current drug or alcohol abuse or dependence, or a history of drug or alcohol
abuse or dependence within 365 days prior to Day 0
- Have a historically positive HIV test or test positive at screening for HIV
- Hepatitis status:
- Serologic evidence of current or past Hepatitis B (HB) infection based on the results
of testing for HBsAg and HBcAb as follows:
- Patients positive for HBsAg or HBcAb are excluded
- Positive test for Hepatitis C antibody
- Have a history of an anaphylactic reaction to parenteral administration of contrast
agents, human or murine proteins or monoclonal antibodies
- Have any other clinically significant abnormal laboratory value in the opinion of the
investigator
- If Women of Child-Bearing Potential (WCBP) are included, please see special
instructions below.
- Have any intercurrent significant medical or psychiatric illness that the investigator
considers would make the candidate unsuitable for the study