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Mitigating Post-Op RV Dysfunction After LVAD Implantation

Recruiting
18 years of age
Both
Phase N/A

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Overview

This project evaluates right ventricle (RV) protective strategies after left ventricular assist device (LVAD) implantation.

Description

The main purpose of this study is to learn more about protecting against RV dysfunction and RV failure (RVF) in patients receiving LVAD implantations.

This is a prospective, randomized controlled study that will include 20 patients with heart failure undergoing LVAD implantation. Patients will receive their LVAD implantation as part of routine care. Patients will be randomized 1:1 to one of two arms, 1) standardized RV management arm, and 2) usual care RV management arm, which are both consistent with standard of care (SOC).

Eligibility

Inclusion Criteria:

  • Age ≥ 18 years
  • Undergoing durable LVAD implantation without plan for perioperative right ventricular mechanical circulatory support

Exclusion Criteria:

  • Patients with pre-operative right ventricular mechanical circulatory support or having high likelihood of requiring right ventricular mechanical circulatory support.
  • Patients with RV implantable cardiac device (ICD)/pacemaker lead who are pacemaker-dependent
  • Pregnant patients

Study details

Heart Failure, Right Ventricular Dysfunction, Right Ventricular Failure

NCT05758194

University of Chicago

25 January 2024

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