Found 65,199 clinical trials
Ivosidenib in Locally Advanced or Metastatic Cholangiocarcinoma With IDH1 R132 Mutation After at Least One Prior Systemic Treatment - an Observational Study
Cholangiocarcinoma is a rare and aggressive tumor of the bile duct associated with a poor prognosis and very limited treatment options. The IDH1 inhibitor ivosidenib provides a new, targeted treatment option for this disease. Ivosidenib was approved by European Medicines Agency (EMA) in May 2023 as monotherapy in adult patients …
Evaluation of an Anti-TREM-1 Treatment on an ex Vivo Human Intestinal Model
TIME is an observational study performed on UC and CD patients under endoscopic surveillance for monitoring the clinical activity of their disease. The main objective of the study is to confirm the therapeutic potential of TREM-1 in inflammatory bowel disease.
Functional Capacity in Anderson-Fabry Disease Patients
The goal of this observational study is to observe the relation between excercise parameters - assessed by CPET - and rest/stress hemodynamic parameters - assessed by echocardiogram and CMR - in patients with a genetic diagnosis of Anderson-Fabry Disease. Participants will undergo: baseline evaluation: clinical evaluation, disease staging with FASTEX …
Exploring Emotional Intelligence and Cognitive Flexibility in Anorexia Nervosa and Parkinson's Disease.
The main aim of this study is to demonstrate how disorders characterized by different types of "inflexibility", cognitive-affective type for Anorexia nervosa and motor one for Parkinson's disease, have an impact on how emotional stimuli are processed and on the transition within emotional states.
The Role of Cxcr4Hi neutrOPhils in InflueNza
Influenza is still responsible for more than 650,000 deaths per year worldwide and no major improvements in patients' care has been made despite 50 years of research. Especially, there is no therapeutic strategy targeting the dysregulated host response. CXCR4-expressing neutrophils seem to be involved in the rupture of host resistance. …
Relationship Between Gross Motor Coordination and Balance in Children With Spastic Cerebral Palsy
This study aims to determine if there is a connection between gross motor coordination and balance in children with spastic cerebral palsy. Since these children often struggle with balance and other motor skills, researchers hypothesize that there is no link between the two abilities.
Pathological Type，Gene Mutation and Clinical Characteristics of Unilateral Primary Aldosteronism
Aim to investigate the pathological feature of UPA in Asians To clarify the relationship between pathology, clinical phenotype, genetic mutation and surgical outcome of UPA in Asians. To explore a new pathological type of unilateral primary aldosterone
Evaluation of Clinical Outcomes of Scaffold Treatment of Partial Meniscal Injuries of the Knee
The study consists of 3 phases (Identification of includable patients, Telephone follow-up evaluation and the collection of study-specific clinical data in medical records of enrolled patients): Identification by trained medical personnel of subjects who meet the study's inclusion criteria. Once the patient's Informed Consent has been obtained, the study-specific questionnaires …
A Multi-omics Study of "Healthy" Premature CAD Patients
The goal of this multi-center observational clinical trial is to investigate the genetic risk factors of patients with premature CAD and none traditional CAD risk factors through a multi-omics approach. The main questions it aims to answer are: Genetic risk factors & metabolic fingerprints of patients with premature CAD and …
Gastric Ultrasound Feeding Tube Placement Confirmation Study
Objective This study aims to assess the accuracy and reliability of ultrasound in determining the correct placement of gastric feeding tubes (GFTs) in intensive care patients. Study Design A diagnostic study will be conducted to evaluate the efficacy of ultrasound in determining GFT placement in all ICU patients who require …
