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A Natural History Study of Patients With GNE Myopathy and GNE-Related Diseases

Background GNE Myopathy is a disease that causes walking difficulties and increasing muscle weakness. It usually develops in young adults (between 20 and 30 years of age), and affects arm and leg muscles. HIBM is caused by mutations in a gene that may affect how the muscles function. Researchers want …

4 - 80 years of age All Phase N/A
X Xiang Zhang, Ph.D

Construction of a Database for TTP

Information about patients was collected by reviewing the Hitech case system and telephone and outpatient follow-up, and the case database was constructed by Epidata software. The sample size is expected to be 200 cases, the participating hospital is the First Affiliated Hospital of Soochow University, and the study time frame …

years of age All Phase N/A
M Melanie Cote

Frailty in Patient Undergoing Percutaneous Left Atrial Appendage Closure.

To assess the prevalence and severity of frailty in patients undergoing LAAC, as well as its association to peri-procedural and long-term outcomes and quality of life.

18 years of age All Phase N/A

Normal Values in Hearing and Balance Testing

Background Researchers at the National Institutes of Health give many tests of hearing and balance. These tests can help detect problems that affect hearing or balance. It is important to know exactly how healthy people perform on each of these tests. This information will indicate when a test result is …

5 - 80 years of age All Phase N/A

Retrospective Study on Characteristics and Outcomes in Hospitalised Patients Treated With Ondexxya

This is an observational retrospective database study of hospitalized patients treated with andexanet alfa in approximately 10 Dutch hospitals. Currently there is limited information on the patient characteristics and outcomes of patients who are treated with andexanet alfa in The Netherlands and how it is used. This is of interest …

18 years of age All Phase N/A
A Anne-Françoise Rousseau, PhD

Acylcarnitine Profile After Intensive Care

The aim of the study is to compare the acylcarnitine profile of critically ill survivors of a prolonged stay in ICU with the profile of survivors of short ICU length of stay. The second aim is to assess the evolution of the acylcarnitine profile over time in survivors of a …

18 years of age All Phase N/A
M Mary Tulke, RN

Musculoskeletal and Pelvic Floor Health in Female Chronic Overlapping Pelvic Pain Conditions

The purpose of this study is to learn about nerve function and pelvic muscle function. To do this we will compare the pelvic nerve and muscle function of women with chronic pelvic pain to those who do not have chronic pelvic pain. Understanding the pain may lead to better treatments …

21 - 80 years of age Female Phase N/A

Imaging of Endolymphatic Hydrops at 7T MRI

Imaging endolymphatic hydrops with 7T Sodium Imaging and 1.5 T gadolinium enhanced imaging: a comparison of diagnostic outcomes with 3T MRI Duration of study 24 months Study design Prospective cohort study Number of patients 16 patients To evaluate whether imaging both 1.5T and 3T have an equivalent performance in terms …

18 years of age All Phase N/A
H Hiromasa Otake, MD

To Evaluate the Efficacy of Alirocumab for Neoatherosclerosis by Using OCT, in Comparison With Standard Statin Therapy

The aim of this study is to evaluate the efficacy of alirocumab for in-stent neoatherosclerosis by using optical coherence tomography, in comparison with standard statin therapy.

20 years of age All Phase N/A
A Alexandra MALGOYRE, MD, PhD

Study of Thermoregulation in Exercise Heat Stroke in the Military Environment

The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and clinical settings. Unlike the walk-run test, it is performed under controlled conditions, both environmentally (temperature control, humidity, …

18 years of age All Phase N/A

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