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Found 65,447 clinical trials

Microdosing ICG for Serial Colonic Perfusion Study During Surgery

using microdosing of ICG vs regular dosing of ICG for perfusion assessment during surgery

18 - 80 years of age All Phase N/A
D Dominique E Bertucci, D.M.D.

The Impact of Medical Play in the Dental Clinic Setting on the Cooperation of Neurotypical Patients

The purpose of this pilot study is to investigate the efficacy of medical play in the dental setting to improve the behaviors and cooperation of neurotypical patients during dental visits. The specific aims of the study are as follows: To evaluate differences in behaviors and cooperation levels of subjects utilizing …

5 - 10 years of age All Phase N/A

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

The purpose of this study to find out whether adding trastuzumab and pembrolizumab to standard chemotherapy is an effective treatment for resectable HER2+ esophagogastric cancer.

18 years of age All Phase 2

A Trial of SHR-A1811 Combined With Other Antitumor Therapies in Advanced Solid Tumors.

The study is being conducted to evaluate the safety, tolerability and efficacy of SHR-A1811 combined with other antitumor therapies in advanced solid tumors. To explore the reasonable dosage of SHR-A1811 combined with other antitumor therapies for advanced solid tumors.

18 - 75 years of age All Phase 1/2
C Clare Morey, MA

Transcutaneous Spinal Cord Stimulation to Promote Walking Recovery After Spinal Cord Injury

The goal of this clinical trial is to investigate the effects of transcutaneous spinal cord stimulation (TSCS) combined with exoskeleton training, as compared to exoskeleton training alone to improve motor function in individuals with incomplete spinal cord injury who are 12 months or less post-injury. Participants will be randomly assigned …

18 years of age All Phase N/A
L Larry Hinkson, FRCOG

Management of Retained Placenta With the "Windmill" Technique of Umbilical Cord Traction

The incidence of leftover placenta after vaginal delivery is between 0.1% and 3.3%, with a maternal mortality of up to 10% reported. The traditional management is ultimately the manual removal of the retained placenta (MROP) in the operating room. However, MROP itself increases the risk of further bleeding, postpartum infection, …

18 - 60 years of age Female Phase N/A
D David Fredricks

Sustained Oral Fiber Supplementation for Patients Undergoing Donor Stem Cell Transplantation for Hematological Malignancies

This clinical trial examines sustained oral fiber supplementation for patients undergoing donor stem cell transplantation for hematological malignancies. Patients undergoing donor stem cell transplantation often develop oral and gastrointestinal damage from chemotherapy, radiotherapy, or graft-versus-host disease. Oral fiber nutrition support may improve overall nutrition, support a normal gut microbiome (bacteria …

18 years of age All Phase N/A
L Lisa Mailleux, MSc, PhD

Upper Limb Somatosensory Discrimination Therapy and Dose-matched Motor Therapy in Children and Adolescents With Unilateral Cerebral Palsy

A randomized, controlled, and evaluator-blinded trial will be carried out to investigate the effects of 8 weeks of upper limb somatosensory discrimination therapy compared to an equal dose of motor therapy on sensorimotor outcomes in children and adolescents with spastic unilateral cerebral palsy aged 7 to 15 years old. Additionally, …

7 - 15 years of age All Phase 2
C Cancer Connect

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

This phase II ComboMATCH treatment trial tests how well AMG 510 (sotorasib) with or without panitumumab works in treating patients with KRAS G12C mutant solid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Sotorasib is in …

18 years of age All Phase 2
S Shima A Mohammad Zadeh

Additional Effect of Forward Head Posture Correction on Temporomandibular Dysfunction

The goal of this clinical trial is to test the additional correction effect of nerd neck on damaged jaw in people who suffers from jaw problems and nerd neck at the same time. The main question it aims to answer: • whether the additional correction of nerd neck impact the …

18 - 40 years of age All Phase N/A

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