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Found 64,920 clinical trials

A Phase III Study of ESG401 for Locally Advanced or Metastatic HR+/HER2- Breast Cancer

The aim of this study is to evaluate the efficacy and safety of ESG401 in patients with unresectable locally advanced or metastatic HR+/HER2- breast cancer.

18 years of age All Phase 3

The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients

The study aims to evaluate the effects of combination of metformin with NAC in PCOS on biochemical and hormonal parameters.

20 - 45 years of age Female Phase 3
Y Ying Sun, BA

Effect of Xuesaitong Soft Capsules on Major Risk Factors in Patients With Coronary Heart Disease

This trials aims to assess, in 240 eligible patients with coronary heart disease, the effects on level of high-sensitivity C-reactive protein (hsCRP) changes from baseline to 12 weeks of Xuesaitong Soft Capsules.

18 years of age All Phase 4
D Dr Masood Ahmed, MBBS Phd

Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients

To evaluate the efficacy of metformin as an adjunct therapy in improving depressive symptoms and metabolic markers in newly diagnosed obese depressed patients on standard antidepressant therapy. investigator will compare between Two groups metformin group 2 placebo group Primary outcome measure will be the improvement in depressive symptoms, indicating by …

18 - 45 years of age All Phase 4
A Aysel TOPÇU, Msc

Exercises for Pes Planus

Pes planus is a musculoskeletal syndrome in which the medial longitudinal arch (MLA) of the foot is reduced or flattened. It results from a combination of static and dynamic abnormalities. Various predisposing factors such as increased weight, foot injury, and musculoskeletal disorders are associated with this problem. In addition, studies …

12 - 18 years of age All Phase N/A
P Pierre-Alexis DE NICE, MD

Contribution of Virtual Reality in the Management of Patients Undergoing Scheduled Cesarean Section - VR-SCS

Cesarean deliveries account for 20.7% of all deliveries in France, according to the latest perinatal survey. At Nice University Hospital, the C-section rate over the last 5 years is around 19%. Caesarean section patients are at greater risk of developing symptoms of anxiety, stress and depression. The post-operative period is …

18 - 45 years of age Female Phase N/A
T Thomas H Beckham, MD,PHD

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic therapy. To learn if using SRS to treat all brain metastases that do not respond to systemic …

18 years of age All Phase 2
R Rebecca Patterson, BSc

Sleep as a Mechanism of Change in Alcohol Use

This project aims to evaluate improvement of insomnia as a mechanism of improvement in alcohol use outcomes.

18 - 49 years of age All Phase N/A
L Louai Razzouk, MD

ELEVATE High-Risk PCI Pivotal Study

The ELEVATE III Pivotal Study is a prospective, multi-center, open-label, interventional, randomized, controlled study with an active control group. The study is intended to assess the safety and efficacy of the Elevate™ percutaneous Left Ventricular Assist Device System in patients referred to high-risk percutaneous coronary interventions (HR-PCI).

18 - 88 years of age All Phase N/A
M Maria Olex, Psy.D.

Music During Allogeneic Stem Cell Transplant Hospitalization

The goal of this trial is to develop an Independent Music Listening tool for stem cell transplant patients that have prolonged hospitalizations. The main questions it aims to answer are: [primary hypothesis or outcome measure 1]? [primary hypothesis or outcome measure 2]? Participants will use a self-guided music listening intervention …

18 - 100 years of age All Phase N/A

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