Found 64,778 clinical trials
VAM in Secondary AML, AML With Extramedullary Involvement, and Myeloid Sarcoma
The mitoxantrone liposomal enhances the tissue permeability of mitoxantrone by incorporating liposomal groups compared to the conventional mitoxantrone formulation, while also reducing the concentration of free mitoxantrone, thereby minimizing drug side effects-particularly cardiotoxicity. Building upon this, the investigators aim to investigate the efficacy and safety of the liposomal mitoxantrone hydrochloride …
The Impact of Exercise Methods on Human Body Functions and Metabolism
The objective of this study is to compare the effects of 8 months of yoga and walking exercise training on weight-related body fat and metabolic biomarkers in women. Participants will be randomly assigned to either a yoga group or a walking group. The yoga group will undergo 90-minute sessions, 3 …
Smartwatches for Detection of Atrial Fibrillation (AFib) in Secondary Prevention of Cryptogenic Stroke
Scientific Background: In secondary prevention of ischemic stroke, detection of atrial fibrillation (AFib) and subsequent anticoagulation therapy reduce the risk of recurrent stroke by approximately 60%. Prolonged electrocardiogram (ECG) monitoring up to 6 months significantly increases detection of AFib in cryptogenic stroke. Wearables like smartwatches have recently been shown to …
The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough. However, the safety, feasibility, and repeatability of this procedure is not widely known. In this study, we will perform ATP cough challenges …
Bacterial Reduction After Supplementary Disinfection Procedures in Infected Root Canals
The purpose of this study is to understand the effect that 3 different types of root canal procedures have on bacteria.
A Study of Ivonescimab in People With Endometrial and Cervical Cancers
The researchers are doing this study to find out if ivonescimab is an effective treatment for people with endometrial cancer (EC) and/or cervical cancer (CC). The researchers will also look at whether the study drug is safe and causes few or mild side effects in participants.
A Mobile App to Improve 24-Hour Movement Guideline Adherence in Preschoolers
The goal of this clinical trial is to evaluate whether a home-based mHealth intervention can improve adherence to the 24-Hour Movement Guidelines in preschool-aged children (3-4 years old) who currently meet 0 or 1 of the guidelines for physical activity, sedentary behavior, and sleep. The main questions it aims to …
The Effect of Multimodal Pain Regimen on Use of Narcotics After Rotator Cuff Tear Repair
The goal of this clinical trial is to understand which group of pain control medications work best in adults after rotator cuff surgery.
Combination Immunotherapy Targeting Melanoma
The purpose of this study is to assess the feasibility, safety and efficacy of combination immunotherapy based on CAR T cells, cytotoxic T lymphocytes (CTLs), and dendritic cell (DC) vaccines modified with GM-CSF and B7-2 (CD86) against melanoma, which targets CAR T specific surface antigens such as GD2, CTL specific …
Virtual Reality to Improve Patient Experience During Endoscopic Mucosal and Submucosal Resection
This study explores the feasibility of using Virtual Reality (VR) to manage pain and anxiety during Endoscopic Mucosal (EMR) and Submucosal Dissection (ESD). EMR and ESD often requires sedation or analgesia, which can cause side effects like respiratory or cardiac suppression. VR, by immersing patients in a calming virtual environment, …
