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Found 64,778 clinical trials
D Dawn Hershman, MD, MS

Opioid Dispensing Device for Post-Operative Pain in Cancer Patients Patients

This research study will evaluate the use of, and participants experience with, a new device called Addinex that safely stores and dispenses opioid medication. The purpose of this study is to evaluate the use of the Addinex device in cancer patients undergoing cancer-related surgery that require pain control with opioids …

18 - 99 years of age All Phase N/A
S Stacey Sellers, MS

Integration of Cognitive Processing Therapy and Relapse Prevention for Alcohol Use Disorder and PTSD

The goal of this clinical trial is to test the efficacy of a novel integrative cognitive-behavioral intervention in patients with posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Specific Aim 1: Examine the efficacy of CPT-RP, as compared to RP alone, in reducing alcohol frequency (percent days drinking) and …

18 - 70 years of age All Phase 2
D Danang A. Yunaidi, MD

Efficacy and Safety of Probiotic Products for Digestive Health

The objective of this study is to evaluate the efficacy and safety of the probiotic product as an everyday gut health product in supporting digestive environment and homeostasis of gut microbiota.

18 - 60 years of age All Phase N/A
L Leonidas Koliastasis, MD, MSc, PhD

Rapid Atrial Pacing After TAVI to Predict Pacemaker Implantation

Despite Transcatheter aortic valve implantation (TAVI) evolution regarding techniques, equipment and experience, the need for permanent pacemaker implantation (PPI) post-TAVI remains an important drawback. The electrophysiology testing to stratify the risk or necessity of PPI post-TAVI is endorsed by the up-to-date guidelines and consensus documents and it is a valuable …

18 years of age All Phase N/A
F François-Clément Bidard, MD

ECLECTIC: EstroTEP and Circulating Biomarkers for ER-positive HER2-negative Metastatic Breast Cancer Patients

Eclectic is a strategy trial; once the class of treatment (endocrine therapy or chemotherapy) has been allocated according to 16α-18F-fluoro-17β-oestradiol (18F-FES) Positron Emission Tomography/Computed Tomography (PET/CT) results and circulating tumor biomarkers, clinicians will decide which treatment to use.

18 years of age Female Phase 3

The Effect of Appropriate Family Companionship on the Physical and Mental Health of Patients With Advanced Breast Cancer

The goal of this clinical trial is to learn about companionship needs in breast cancer patients who are pathologically or cytologically diagnosed as cancer, are alive with the tumor, and have TNM clinical stage IV. The main questions it aims to answer are: Patients with advanced breast cancer need family …

21 - 72 years of age Female Phase N/A
A Atef Mohamed Sayed, MS.C

Quality Of Recovery After Pericapsular Nerve Group (PENG) Block For Hip Hemiarthroplasty Under Spinal Anesthesia

Patients undergoing hip hemiarthroplasty can benefit significantly from regional anesthesia in terms of pain management and recovery . There is a wide range of regional anesthetic techniques. The most common in this anatomical region and those with the greatest published research are fascia iliac block, lumbar plexus block, and femoral …

18 - 80 years of age All Phase N/A
D Daniel J Corwin, MD, MSCE

Facilitating Access to Specialty Treatment

The goal of this hybrid implementation-effectiveness study is to evaluate the effectiveness (hastened recovery times) and feasibility (fidelity in connecting to concussion specialty care) of a novel mobile health intervention, designed to reduce disparities in access to specialty care through the use of remote patient monitoring (RPM) to facilitate care …

13 - 18 years of age All Phase N/A
L Lei Wang, M.D

Study on Heart Failure With Preserved Ejection Fraction With Qishen Granules

With the cardiopulmonary exercise testing as the primary outcome, the study aims to evaluate the efficacy of Qishen Granules on cardiac function, quality of life and biomarker level of patients with heart failure with preserved ejection fraction (HFpEF), which will provide evidence for the treatment of HFpEF with traditional Chinese …

18 - 85 years of age All Phase N/A
H Hongyun Zhao

A Study of Recombinant Oncolytic Virus M1(VRT106) in Patients With Solid Tumors

To Evaluate the safety and tolerability of single and multiple intratumoral injections of recombinant oncolytic virus M1 (VRT106) in patients with locally advanced/metastatic solid tumors.

18 - 75 years of age All Phase 1

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