Chevy Chase, Maryland Clinical Trials

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy

Background Medical advances have improved survival rates for many cancers and other illnesses. This means that more people are coping with the long-term effects of these treatments. Some treatments can cause female infertility. Ovarian tissue cryopreservation (OTC) may help. Before undergoing a treatment that may damage their fertility, patients may …

C Chris Koh, MD

Drug-Induced Liver Injury (DILI) Network Retrospective

The purpose of this study is to establish retrospectively a nationwide registry of patients who have suffered drug-induced liver injury (DILI), and to collect, immortalize, and store serum, DNA, and lymphocytes from these patients. ILIAD will serve as a resource for subsequent mechanistic investigations into the basis of severe idiosyncratic …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)

Background Alcohol use disorder (AUD) is the most common substance use disorder in the world. Long-term AUD can affect a person s sense of taste and smell. This natural history study will compare alcohol drinking behaviors and measures of taste and smell in people with and without AUD. Objective To …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity During the COVID19 Pandemic

Background Mitochondrial disease is a rare disorder. It can cause poor growth, developmental delays, muscle weakness, and other symptoms. The disease is usually inherited. It can be present at birth or develop later in life. Infection is a major cause of disease and death in people with this disease. Researchers …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Investigational Use of Neuromuscular Ultrasound

Background Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Researchers are looking for ways to improve the ability to observe nerves and muscles and how they function in this natural history protocol. Objective To …

Rod and Cone Mediated Function in Retinal Disease

Background Retinal diseases cause the loss of rod and cone photoreceptors. Symptoms include vision loss and night blindness. Researchers want to learn about rod and cone function in healthy people and people with retinal disease. They want to know if how well a person sees in the dark can test …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Metabolic Profiling of Immune Responses in Immune-mediated Diseases

Background The immune system is the part of the body that fights infection. Some people have immune deficiencies that cause skin rashes, make them get sick often with infections, or make it difficult for their skin to heal. Researchers want to learn more to better treat conditions that affect immune …

A An Dang Do, M.D.

MEHMO Natural History and Biomarkers

This observational natural history study will follow individuals with MEHMO (Mental disability, Epileptic seizure, Hypopituitarism/Hypogenitalism, Microcephaly, Obesity) syndrome or an eIF2-pathway related disorder, who have symptoms such as intellectual delay, seizures, abnormal hormone and blood sugar levels, and decreased motor skills. No current treatment for these conditions is available. A …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Characterization of Dysmorphology in Subjects With Creatine Transporter Deficiency

Background Creatine transporter deficiency (CTD) is a genetic disorder that mainly affects the brain in males. CTD causes intellectual disability that can be mild to severe. People with CTD may have seizures and behavioral issues. They may have slow growth and tire easily. CTD may sometimes be confused with autism …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Gonadal Tissue Freezing for Fertility Preservation in Individuals at Risk for Ovarian Dysfunction, Premature Ovarian Insufficiency and Clinically Indicated Gonadectomy

Background Turner Syndrome, galactosemia, and premature ovarian insufficiency are all conditions that may make it very hard or impossible for a person to become pregnant and have their own child. Researchers want to learn more about why this happens and if freezing Gonadal tissue allows for fertility preservation. Objective To …