Minatoga, Japan Clinical Trials

S Steve Williamson, MD

Using Ex Vivo Tumoroids To Predict Immunotherapy Response In NSCLC

To test whether it is feasible to perform the 3D-EX functional predictive response bioassay in the context of patients with advanced/metastatic NSCLC receiving immune checkpoint inhibitors in the standard of care clinical setting.

A Amy C Killeen, DDS, MS

Association of Periodontal Inflammation on Immune Response in Wound Healing

Subjects who are in need of extraction of a posterior tooth will be recruited for this study. Prior to extraction, periodontal clinical markers of inflammation, body-mass index and dental radiographs will be measured/taken. The posterior tooth will be atraumatically extracted and a small soft tissue biopsy of the extraction site …

F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Influence of Brain Oscillation-Dependent TMS on Motor Function

Background When people have a stroke, they often have difficulty moving their arms and hands. Transcranial magnetic stimulation (TMS) can improve how well people with and without stroke can move their arms and hands. But the effects of TMS are minor, and it doesn t work for everyone. Researchers want …

A Abdellatif TAZI, MD PhD

Adult Pulmonary Langerhans Cell Histiocytosis: a National Registry-based Prospective Cohort Study

The long-term outcomes of adult patients with pulmonary Langerhans cell histiocytosis (PLCH), particularly survival, is largely unknown. This is the first prospective study in the field evaluating the long-term outcomes of PLCH patients. This french countrywide registry-based study included a large cohort of PLCH patients followed for a sufficiently long …

An Observational Study to Assess Ubrogepant Tablets and Atogepant Tablets to Treat Migraine in Adult Participants

Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate how effective the use of ubrogepant and atogepant is in treating adult participants with migraine. Urogepant (Ubrelvy) and Atogepant (Qulipta) are approved drugs for treatment …

I Isaac Cebrecos, MD

TAD After Chemotherapy in Locally Advanced Breast Cancer

This is an observational study to validate target axillary dissection (TAD) in locally advanced tumors (cN2 and/or cT4).

F FU-WEI SU, MD

Ultrasound Needle Transducer for Regional Anesthesia Validation Study

To validate the efficacy of miniaturized ultrasound needle transducer as the primary guide for thoracic regional anesthesia.

K Kathy Han, MD

LANDscape MApping of Epitopes and T Cell Receptors for Selected Cancers

This is a correlative research project aimed at characterizing the T cell mediated immune responses to hepatocellular carcinoma (HCC), as well as Epstein-Barr virus (EBV)- and human papillomavirus (HPV)-related cancers. This study will enroll approximately 105 patients over 48 months. Of these 105 patients, 30 are EBV-related cancer, 45 are …

C Carmen Escuriola-Ettingshausen, MD

Treatment of Hemophilia A Patients With FVIII Inhibitors

This is a non-interventional, multicenter, observational, international study in male persons with haemophilia A who have developed inhibitors to any replacement coagulation factor VIII (FVIII) product. The purpose of the study is to capture different approaches in the management of persons with haemophilia A and FVIII inhibitors, document current immune …

S Susan Luo, MD；PHD

Study of Myasthenic Crisis in China

This study is a multicenter, prospective, observational research. It will register the basic demographic information, medical history characteristics, clinical features, auxiliary examinations, treatment, outcomes of tracheal intubation/ventilator related events, and clinical outcomes of Myasthenic Crisis patients. The objectives including: Obtain epidemiological data of MC in China; Establish a standardized registration …