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Cergy-pontoise, France Clinical Trials

A listing of Cergy-pontoise, France clinical trials actively recruiting patients volunteers.

Found 71 clinical trials
T Thierry DEBILLON

Respiratory Effect of the LISA Method With Sedation by Propofol Versus Absence of Sedation.

The investigators propose to evaluate premedication with Propofol compared to a control strategy including a placebo with a possible rescue treatment with ketamine to ensure pain control before LISA Procedure . Investigators hypothesize that sedation with Propofol is safe and non-inferior to placebo for the risk of Mechanical Ventilation in …

- 100 years of age Both Phase 3

Non-invasive Early Oxygen- Reserve-index (ORI) Determination to Prevent Hypoxaemia During Endotracheal Intubation

The purpose of this study is to determine whether ORI monitoring increases the lowest oxygen saturation level during the interval between the first laryngoscopy (defined as introduction of the laryngoscope into the mouth) and the end of the second minute after successful ETI.

18 - 100 years of age Both Phase N/A

Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders

Rheumatoid arthritis (RA) is the most common inflammatory rheumatoid disease in France, affecting 0.3% of the general population. Without effective treatment, the persistent inflammation causes invalidating pain and joint destruction, leading to major functional disability. Biological agents have been proposed for patients with RA who have the most severe form …

18 - 100 years of age Both Phase 4
C Caroline Legal

Effect of Tourniquet Abstention on Pain Reduction in Venous Sampling in the Elderly People

This prospective study evaluates the effect of abstaining from tourniquets on pain reduction during the venous puncture of the elderly people.

75 - 100 years of age Both Phase N/A
M Marlène OCHMANN, MD

STop and Restart Acalabrutinib In fRail Patients With Previously Untreated Chronic Lymphocytic Leukemia

The irreversible Bruton's Tyrosine Kinase (BTK) inhibitor acalabrutinib (ACA) has potent clinical activity as a single agent in patients with treatment naive and Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL). However, a growing body of concerns is raising regarding the unlimited administration of targeted therapy as BTKi. First, long-term treatments expose the …

70 - 100 years of age Both Phase 2
D Dominique Pejoan

Efficacy of Non-instrumental Pleural Chest Physiotherapy

The main purpose of this study is to assess efficacy of non instrumental pleural chest physiotherapy on the recovery of respiratory function, at hospital discharge or 15 days after beginning the pleural chest physiotherapy, compared to physiotherapy with standard mobilization, in patients with infectious pleural effusion, who have received usual …

18 - 100 years of age Both Phase N/A
H Hiroshi Shinyama, PhD

International Validation Study of Sentinel Node Biopsy in Early Cervical Cancer

SENTICOL III is large prospective multicenter international randomized study designed to validate the Sentinel Lymph Node (SLN) mapping technique in early cervical cancer. This "validation study" will compare the outcome of patients with negative SLN (experimental arm) vs patients with negative SLN + Pelvic Lymph Node dissection (PLN)(reference arm). There …

18 - 100 years of age Female Phase N/A
A ASFAR Pierre, MD-PhD

Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock

The best strategy for managing fever in patients with septic shock remains unknown. In a pilot study, the investigators showed that fever control at normothermia allowed a better control of shock and evolution of organ failures. In this second trial the investigators will conduct a multicentre, open-label, randomized controlled, superiority …

18 - 100 years of age Both Phase N/A

Safety and Efficacy of AON-D21 in Severe Community-Acquired Pneumonia.

The goal of this clinical trial is to compare the safety and efficacy of AON-D21 versus placebo, both on top of standard of care, in patients with severe community acquired pneumonia admitted to ICU (or similar unit). The main questions to answer are: The safety and tolerability of AON-D21 vs …

18 - 85 years of age Both Phase 2

Collaborative Mental Health Care Model: an Evaluation of the Implementation of a Pilot in Four Primary Care Organization

Frequent mental disorders (anxiety or mood disorders), an important part of primary care patient care, remain insufficiently detected and treated. Improving their care requires better coordination between general practice and specialized care. The collaborative care model developed in Washington State with the introduction of a care manager is recognized. About …

18 - 100 years of age Both Phase N/A

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