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mild-cognitive-impairment Clinical Trials

A listing of mild-cognitive-impairment medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 696 clinical trials

A Study to Learn About the Safety of BIIB080 and Whether it Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age

In this study, researchers will learn more about a study drug called BIIB080. The study will focus on participants with mild cognitive impairment or mild dementia due to AD. The main question researchers are trying to answer is if BIIB080 can slow the worsening of AD more than placebo. It …

50 - 80 years of age Both Phase 2
M Mehmet I Naharci, Assoc.Prof.

Modified Ketogenic Diet in Amnestic Mild Cognitive Impairments

This clinical study aims to examine the effectiveness of a 12-week modified ketogenic diet (MKD) intervention, especially on cognitive functions, in individuals diagnosed with amnestic-mild cognitive impairment (aMCI) and to compare the effects of control groups (passive or active). Accordingly, a sample of 36 older adults aged 65-80 years diagnosed …

65 - 80 years of age Both Phase N/A
N Neda Rashidi-Ranjbar, MD, PhD

Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI)

There are over 50 million people living with dementia, and by 2050, the number is expected to rise to 152 million worldwide. Mitochondrial dysfunction in the brain of MCI and AD patients is gaining prominence as a potential mechanism and thus treatment target. However, an effective therapy targeting mitochondrial function, …

50 - 95 years of age Both Phase N/A
C Callie Hebert, MS

Reducing African American's Alzheimer's Risk Through Exercise-Mild Cognitive Impairment (RAATE-MCI)

The RAATE-MCI proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. RAATE-MCI is a 52-week randomized controlled trial. 144 African American adults aged 60 and …

60 - 100 years of age Both Phase N/A
P Philip Gerretsen, MD, PhD

Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment

The goal of this clinical trial is to investigate the effects of psilocybin on synaptic vesicular density (SVD) as measured by the positron emission tomography (PET) radiotracer, 18F-SynVesT-1, in participants with amnestic Mild Cognitive Impairment (aMCI) and healthy participants. The investigators hypothesize that SVD levels in the brain will be …

60 - 75 years of age Both Phase 2
J Joseph Gullett, Ph.D.

Training Response Artificial Intelligence Network (TRAIN)

This study will train a machine learning tool to predict response to a cognitive training intervention using baseline brain MRI sequences from older adults with amnestic mild cognitive impairment.

55 - 100 years of age Both Phase N/A
F Francisco Garcia Torres, PhD

Unified Barlow Protocol (UP) in Cancer Survivors for Cognitive Impairments

Background: Cognitive impairment appears frequently in cancer survivors, negatively affecting the quality of life and emotional well-being of patients. This study compares the effectiveness of a well-established treatment (cognitive rehabilitation) with the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) to alleviate these cognitive deficits and evaluate its effect …

18 - 70 years of age Both Phase N/A
C Chih-Ping Chung, MD PhD

Effects of Mediterranean Diet on Subjective Cognitive Decline

Research Questions: Due to the fact that most participants in past clinical trials on the Mediterranean diet were cognitively healthy individuals, and while the observed effects were significant, they were not particularly substantial, does the Mediterranean diet have similarly significant and more pronounced effects on both physical and cognitive functions …

60 - 100 years of age Both Phase N/A
T Tait Palm, B.S.

Amantadine Therapy for Cognitive Impairment in Long COVID

This study will look at the effects of amantadine on cognitive function in persons with Long COVID. It will also collect specimens to study possible causes of cognitive symptoms in Long COVID, and whether any lab tests can predict who will respond better to amantadine.

18 - 100 years of age Both Phase 1

Biomarkers of Sleep-wake Cycle in Prodromal Alzheimer's Disease: Role in Cognitive Decline?

Alzheimer's disease (AD) is characterised by a progressive loss of memory and cognitive function. In the early stages of AD, there is a progressive accumulation of molecules: β-amyloid peptides (Aβ) in the brain. There is a link between the accumulation of Aβ peptides and the deterioration of sleep, but current …

50 - 85 years of age Both Phase N/A

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