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hepatic-porphyria Clinical Trials

A listing of hepatic-porphyria medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 7 clinical trials

INcreased Sun Exposure Without Pain In Research Participants With EPP or XLP

To investigate the efficacy of MT-7117 on time to onset and severity of first prodromal symptoms (burning, tingling, itching, or stinging) associated with sunlight exposure in adults and adolescents with EPP or XLP.

12 - 75 years of age Both Phase 3

Effect of Oral Cimetidine in the Protoporphyrias

Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) result from genetic defects of heme biosynthesis that cause life-long, painful cutaneous sensitivity to light. The objective of this study is to determine the efficacy and safety of oral cimetidine administration for treatment of the protoporphyrias. Efficacy will be based on protoporphyrin levels, …

15 - 100 years of age Both Phase 2
I Ida M Heerfordt, MD, PhD

Protection Against Visible Light by Dihydroxyacetone in Erythropoietic Protoporphyria

What is the visible light protective effect of dihydroxyacetone in individuals with erythropoietic protoporphyria? This will be tested in this randomized blinded placebo controlled study.

18 - 100 years of age Both Phase N/A

Pharmacokinetics of Afamelanotide in EPP Patients

The purpose of this study is to evaluate the concentration of afamelanotide in serum after the administration of afamelanotide in adolescent and adult EPP patients.

12 - 70 years of age Both Phase 1/2

ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)

This global patient registry is being conducted to characterize the natural history and real-world clinical management of patients with AHP, and to further characterize the real-world safety and effectiveness of givosiran and other approved AHP therapies.

12 - 100 years of age Both Phase N/A
C Csilla Hallberg, MD

Longitudinal Study of the Porphyrias

The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders.

- 100 years of age Both Phase N/A
C Chloe Cheung

Identification of Acute Intermittent Porphyria Modifying Genes

This study proposes to identify the predisposing/protective modifying genes that underlie the acute attacks in symptomatic patients with Acute Intermittent Porphyria (AIP), an autosomal dominant inborn error of heme biosynthesis.

12 - 100 years of age Both Phase N/A

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