Advanced Filters
noise

chordoma Clinical Trials

A listing of chordoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 18 clinical trials
F Ferdinando Cananzi, MD

Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease

Comparative study on surgery versus definitive radiation therapy in primary localized sacral chordoma

18 - 80 years of age Both Phase N/A
Z Zan Chen, MD

Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordoma

This phase II trial studies how well Camrelizumab combined with Apatinib work in treating participants with chordoma that has spread to other places in the body, which may interfere with the ability of tumor cells to grow and spread.

18 - 100 years of age Both Phase 2
A Anthony P. Conley, MD

Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma

This is a multicenter, single arm, phase 2 study designed to evaluate the efficacy and safety of cetuximab for the treatment of advanced (unresectable)/metastatic, chordoma. The target patient population will be any chordoma patient 18 years of age with locally unresectable disease or metastatic disease.

18 - 100 years of age Both Phase 2
M Morena Sallabanda, MD PhD

Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base

The project is planned as a phase II clinical trial with a low level of intervention, for the prospective evaluation of the clinical results of radical or adjuvant treatment by proton therapy in chordomas and chondrosarcomas of the skull base using hypofractionation schemes in 5 fractions, with the aim of …

18 - 100 years of age Both Phase N/A

Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression.

Non-randomized, open, two-cohort, phase II, multicenter national clinical trial. 20 sites in Spain. Cohort 1 includes soft-tissue sarcoma and osteosarcoma (21 patients), while Cohort 2 includes chordoma patients only (19 patients). Palbociclib will be administered orally at a dose of 125 mg once a day for 21 consecutive days followed …

18 - 80 years of age Both Phase 2

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy

Thanks to the intrinsic qualities of the proton beam, proton therapy will reduce adverse effects of irradiation. The Proteus®One is the latest generation of proton therapy equipment, enabling the Centre Antoine Lacassagne to expand its range of treatments by carrying out new proton therapy treatments. It has an innovative compact …

18 - 100 years of age Both Phase N/A
S Susan Chi, MD

Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

This research study involves a combination of three drugs given together as a possible treatment for malignant rhabdoid tumor, atypical teratoid rhabdoid tumor, epithelioid sarcoma, chordoma or other tumors that are deficient in one of two possible proteins, either INI-1 (SMARCB1) or SMARCA4. The names of the study drugs involved …

6 - 21 years of age Both Phase 1/2
C Cassie Kline, MD

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

This clinical trial is studying two immunotherapy drugs (nivolumab and ipilimumab) given together as a possible treatment for INI1-negative tumors.

6 - 40 years of age Both Phase 2
Z Zan Chen, MD. PHD.

A Prospective Study of Surgical Treatment Strategies for Chordoma

Chordoma is a rare but locally invasive cancer that arises from the embryonic notochord. Total resection is challenging in mobile spine because of the complex anatomy and bone invasion.

18 - 70 years of age Both Phase N/A
P Pascal POMMIER

Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors

This is a transnational prospective randomized trial comparing definitive carbon ion therapy versus photon or combined photon and protontherapy as standard treatment for unresectable or macroscopically uncompleted resected radioresistant tumors. Eligible tumors are axial chordoma (except of base of skull), adenoid cystic carcinoma of head and neck (except of trachea) …

18 - 100 years of age Both Phase N/A

Rewrite in simple language using AI