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precancerous-condition Clinical Trials

A listing of precancerous-condition medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 375 clinical trials
H H. Messmann

Prospective Endoscopic Follow-up of Patients With Submucosal and High Risk Mucosal Esophageal Adenocarcinoma

Aim of this prospective multicenter study is to evaluate the safety of an endoscopic follow-up strategy in patients treated with endoscopic resection (ER) for submucosal or high-risk mucosal esophageal adenocarcinoma (T1bN0M0 or HR T1aN0M0 EAC).

18 - 100 years of age Both Phase N/A

Use of Elranatamab in Patients With High-risk Smoldering Multiple Myeloma

This is a multicenter, single arm, open-label, Phase 2 study in high risk smoldering myeloma patients. The primary objective is to determine the efficacy of Elranatamab in patients with previously untreated high-risk SMM. The key-secondary objective is to determine the safety of Elranatamab in patients with previously untreated high-risk SMM.

18 - 100 years of age Both Phase 2
M Molly Stewart

Minimally Invasive Molecular Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma

This study will evaluate if the sponge capsule device can accurately detect the presence of Barrett's Esophagus and prevalent dysplasia/adenocarcinoma detection, in a screening population, with and without chronic gastroesophageal reflux disease.

18 - 90 years of age Both Phase N/A
S Sandra Boimbo

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

The purpose of this study is to learn the best approach to treating patients with known or suspected Barrett's esophagus by comparing endoscopic surveillance to endoscopic eradication therapy. To diagnose and manage Barrett's esophagus and low-grade dysplasia, doctors commonly use procedures called endoscopic surveillance and endoscopic eradication therapy. Endoscopic surveillance …

18 - 89 years of age Both Phase N/A
M Mankanwal Sachdev, MD

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

The purpose of this research study is to learn about the best approach to sample patients with known or suspected Barrett's esophagus (BE) by comparing the standard Seattle biopsy protocol to sampling using wide area transepithelial sampling (WATS3D). Barrett's esophagus is a common condition that is used to spot patients …

18 - 89 years of age Both Phase N/A
D Diogo Libanio, MD PhD

SUrveillance of PREMalignant Stomach - Individualized Endoscopic Follow-up

Introduction: Gastric atrophy and intestinal metaplasia are the principal precursors for gastric cancer and, therefore, are considered gastric premalignant conditions. Although current guidelines recommend surveillance of individuals with these conditions, the best method for its identification and staging (histological vs endoscopy) and the best time schedule for follow-up are still …

45 - 100 years of age Both Phase N/A

Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer

The goal of this study is to characterize and validate a signature of circulating biomarkers in plasma, associated with the presence of gastric preneoplasia in patients with preexisting gastric lesion compared with a control group. For this purpose: Patients with pre-existing gastric lesions will be invited to participate to this …

18 - 100 years of age Both Phase N/A
J Jackton Omoto, MD

Artesunate Pessaries (Vaginal Inserts) for Cervical Precancer in Kenya

To investigate the use of self-administered artesunate vaginal pessaries as treatment for cervical precancer in low and middle-income countries (LMIC). The central hypothesis of this study is that self-administered intravaginal Artesunate will be safe, and result in a clinical response among both HIV-positive and HIV-negative women with cervical precancer in …

18 - 100 years of age Female Phase 1
D Deborah J. Wong

Pembrolizumab in Treating Participants With Leukoplakia

This phase II pilot trial studies how well pembrolizumab works in treating leukoplakia. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.

18 - 100 years of age Both Phase 2
H Head of Clinical Operations

A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V

The CUV152 study will evaluate the safety of afamelanotide in XP-C and XP-V patients, as well as the drug's ability to assist reparative processes following ultraviolet (UV) provoked DNA damage of the skin. It will assess whether SCENESSE® increases the amount of UV light needed to cause DNA damage of …

18 - 75 years of age Both Phase 2

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