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acute-pain Clinical Trials

A listing of acute-pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

Found 358 clinical trials
F For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

Neural and Psychological Mechanisms of Pain Perception

Background Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect different levels of pain …

18 - 50 years of age All Phase N/A
M Melissa Day, Ph.D.

The Effects and Mechanisms of Brief Mindfulness Meditation and Hypnosis for Pain

The aim of this study is to determine the effects and mechanisms of 1 x 20-min training in mindfulness meditation and self-hypnosis relative to an inert control. Participants will be randomly assigned to condition. The dual primary outcomes will be pre- to post-training changes in current pain intensity and pain …

18 years of age All Phase N/A
E Elizabeth Felix, PhD

Association Between Body Composition and Pain in Spinal Cord Injury

The purposes of the study are to quantify and compare relationships among acute changes in inflammatory markers and evoked pain sensitivity after a high-fat meal (HFM) challenge, compared to a moderate-fat meal challenge, and explore the influence of body composition on these responses, in individuals with chronic spinal cord injury

18 - 65 years of age All Phase N/A
M Michele Steinkamp, RN

Chronic Pain Diagnosis and Treatment in Torture Survivors

The goal Aim 1 of this investigation is to characterize the diagnosis of chronic pain in torture survivors. The investigators hypothesize that using a validated pain screen to supplement the existing United Nations Istanbul Protocol can improve the ability to detect pain from 15% to 90% in this study population. …

18 years of age All Phase N/A
m massimiliano gilli, dr

Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery

The goal of this clinical trial is to evaluate whether the topical application of Novox® Drop on surgical wounds after the extraction of lower third molars can have a clinical advantage. The primary objective of the study is to evaluate the possible reduction of masseteric trismus (masticatory muscle spasm - …

18 - 35 years of age All Phase N/A
L Linda McLean, PhD

Is Repetitive Transcranial Magnetic Stimulation Effective in Reducing Endometriosis-associated Pain

The goal of this research is to improve pain outcomes for the over 500K Canadian women, girls and gender-diverse individuals who are newly diagnosed with endometriosis each year. Chronic pain that persists after interventions for endometriosis is a huge problem. There is some evidence that endometriosis-associated pain (EAP) is, at …

18 - 60 years of age Female Phase N/A
L Laura Porter, Ph.D

Pain With Dementia

The purpose of the study is to develop a caregiver-assisted pain coping skills training program for older adults who have pain and mild to moderate dementia and are living at home with a family caregiver. The investigators are planning to recruit 30 patient-caregiver dyads (60 individuals).

50 years of age All Phase N/A

The Effect of Distraction Techniques Used in Intramuscular (IM) Injections on Pain in Adolescents Presenting to the Emergency Department With Dysmenorrhea: A Randomized Controlled Study

Brief Summary: This study investigates the effectiveness of non-pharmacological techniques for managing dysmenorrhea (menstrual pain) in adolescents. The study focuses on methods such as Helfer Skin Tap Technique (HSTT) and ShotBlocker, which aim to reduce pain without medication. The goal is to determine how these techniques can help adolescents manage …

12 - 18 years of age Female Phase N/A
B Betsy Moclair

Trans-arterial Embolization for the Treatment of Facet Pain Due to Facet Arthropathy

This single-site, single-arm study evaluates the feasibility, safety, tolerability, and efficacy of trans-arterial embolization (TAE) using Embozene microparticles for treating facetogenic pain due to facet arthropathy (osteoarthritis of the facet joints) in the lumbar spine.

18 - 85 years of age All Phase N/A
D David Gomez Varela, PhD

Balance, Autonomic Response, and Sensory Modulation to Dosage of Mechanical Vagal Stimulation in Healthy Adults

The vagus nerve (VN) plays a crucial role in regulating vital functions (heart rate, blood pressure, digestion, and immune response) and maintaining communication between internal organs and the brain. Recent studies have highlighted the therapeutic potential of VN stimulation (VNS) in treating various conditions such as drug-resistant epilepsy, postural control …

18 - 60 years of age All Phase N/A

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